Mammarena viruses Database

Vaccinomics and RNA-based Therapeutics Database for Hemorrhagic Fever-causing Mammarena viruses


Mammarenavirus (mammalian arenaviruses) is an important genus of the animal viruses and accommodates in the family called Arenaviridae. The human infecting seven mammarenaviruses associated with causing viral hemorrhagic fever are named as Lassa virus (LASV), Chapare virus (CHAPV), Lujo virus (LUJV), Guanarito virus (GTOV), Junín virus (JUNV), Machupo virus (MACV), and Sabiá virus (SABV). Demographically, LASV and LUJV are considered indigenous to Africa where as CHAPV, GTOV, JUNV, MACV, and SABV are common in American countries.These are basically enveloped and spherical viral particles with a diameter of 50 to 300 nm. The genome consists of two single-stranded (RNA) molecules known as L (large) and S (small) segments. Each genomic segment is responsible for production of two different proteins whereas L segment serves as a genomic code for zinc binding matrix protein (Z) and viral RNA-dependent RNA polymerase (L). Similarly, S segment encodes an envelope glycoprotein precursor (GPC) and a nucleoprotein (NP). This platform based on extensive genomic and protein specific investigation provides with putative vaccine designs and RNA therapeutics options for utility in both advanced computational and experimental research.